BRUNNER SYNDROME: FROM GENETICS TO PSYCHIATRY - CASE REPORT

Introduction Monoaminergic neurotransmitters affect motor control, emotions and cognitive functions. Their relative abundance depends on the action of monoamine oxidase A (MAOA) which catalyses their degradation into inactive metabolites. Brunner syndrome is a rare chromosome X-linked recessive inheritance genetic disorder, causes loss function MAOA gene, leading to increase in monoamines affected individuals (typically males). It manifests with moderate intellectual developmental disturbance associated maladaptive externalising behaviours, low frustration tolerance marked impulsivity. Objectives To present clinical case patient diagnosed Syndrome presenting suicidal homicidal ideation discuss it based non-systematic review literature. Methods Case report Results: Report Male born neonatal asphyxia that consequently presented retardation characterised by learning difficulties emotional dysregulation. At 18 years age, he began follow-up Psychiatry due self-injurious behaviours several reactive suicide attempts (SA), being Intellectual Disability. 22, was hospitalised depression, discharged doing well valproate, fluoxetine olanzapine. Shortly after, arrested (aged 23-28) for attempted murder followed SA. During imprisonment, Brunner’s after his younger brother diagnosis. 31, ideation, revealing high impulsiveness tolerance, compulsory psychiatric treatment. Three weeks later again symptoms recurrence having improved Sertraline 50mg Aripiprazole 400mg monthly. Discussion Although scarce, available evidence suggests dietary modifications use selective serotonin reuptake inhibitors may improve behaviour, reduce serotoninergic possibly reverse some neurochemical abnormalities. Conclusions disorder neuropsychiatric manifestations, whose course, treatment prognosis are currently poorly known. Thus, current empirical further studies needed. Disclosure Interest None Declared